Universal ICU Decolonization: An Enhanced Protocol

Agency for Healthcare Research and Quality (AHRQ)

This enhanced protocol is based on materials successfully used in the REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-resistant Staphylococcus aureus), which found that universal decolonization was the most effective intervention. Universal decolonization led to a 37 percent reduction in MRSA clinical cultures and a 44 percent reduction in all-cause bloodstream infections. This protocol will provide you with instructions for implementing universal decolonization in adult intensive care units (ICUs).